Electrochemical paper-based antigen sensing platform using plant-derived monoclonal antibody for detecting SARS-CoV-2Article Published on 2023-01-012022-11-15 Journal: Talanta [Category] SARS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 antibody Antigen applicability applied approach Cellulose Concentration COVID-19 diagnosis CR3022 detect diagnostic Differential pulse voltammetry expressed functional group limit of detection linear relationship monoclonal antibody nasopharyngeal swab sample Nicotiana benthamiana Paper-based electrochemical immunosensor Plant-based antibody platform point-of-care pulse quantification RBD Receptor binding domain Saliva SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Spike protein the RBD this system was performed [DOI] 10.1016/j.talanta.2022.123783 PMC 바로가기
The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach새로운 SARS-CoV-2 변이체 Omicron(B.1.1.529)이 백신 효능에 미치는 영향, Delta 변이체와의 상관관계: 전산적 접근Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Analysis antibody approach AY.1 B.1.1.529 binding affinity caused computational analysis correlation COVID CR3022 Delta Delta variants docking docking analysis domain Effect Efficacy Host hosts human ACE2 receptor human monoclonal antibodies Human monoclonal antibody immune evasion in silico Approach In-silico analysis Interaction lead MD simulation Modification Mutation neutralizing antibody new SARS-CoV-2 omicron Omicron variant Omicron. pathogenicity promote Proteins RBD RBD variant Reinfection SARS-CoV-2 variant Spike proteins Strains Structure the binding affinity the WHO Vaccine variant [DOI] 10.1016/j.micpath.2022.105619 PMC 바로가기 [Article Type] Article
A broad and potent neutralization epitope in SARS-related coronavirusesSARS 관련 코로나바이러스의 광범위하고 강력한 중화 에피토프Article Published on 2022-07-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.529 benefit conserved conserved epitope coronavirus CR3022 cross-neutralizing cross-neutralizing antibody Effectiveness elicited epitope high potency Interaction NAbs natural infection neutralization neutralize Neutralizing antibodies neutralizing antibody omicron RBS receptor binding site reduced respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronavirus SARS-related coronaviruses therapeutic therapeutic antibodies vaccination Vaccine variants variants of concern variants of concern. VOCs X-ray X-ray crystallography [DOI] 10.1073/pnas.2205784119 PMC 바로가기 [Article Type] Article
Impact of B.1.617 and RBD SARS-CoV-2 variants on vaccine efficacy: An in-silico approachB.1.617 및 RBD SARS-CoV-2 변이체가 백신 효능에 미치는 영향: In-silico 접근Article Published on 2022-07-012022-09-11 Journal: Indian journal of medical microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 affecting angiotensin antibody Antibody neutralization approach B.1.617 binding affinity conformational COVID-19 vaccine COVID-19 vaccines CR3022 determine docking docking analysis effective Enzymes Factor genomic Genomic surveillance greater higher affinity Immune escape Impact IMPROVE in silico in-silico India Infection Interaction less majority management MD simulation molecular molecular dynamics molecular interaction neutralization performed RBD RBD region RBD variant RBD variants receptor Replication responsible SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant second wave Seven Spike protein stability Surveillance the disease the RBD the spike protein Transmissibility Vaccine vaccine efficacy vaccine efficacy. variant variants virulence wild type wild-type strain Wuhan Wuhan, China [DOI] 10.1016/j.ijmmb.2022.03.009 PMC 바로가기 [Article Type] Article
Antibody-nanobody combination increases their neutralizing activity against SARS-CoV-2 and nanobody H11-H4 is effective against Alpha, Kappa and Delta variants항체-나노바디 조합은 SARS-CoV-2에 대한 중화 활성을 증가시키고 나노바디 H11-H4는 알파, 카파 및 델타 변이체에 대해 효과적입니다.Article Published on 2022-06-112022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibodies antibody association Beta binding binding affinity combating Combination complex COVID-19 CR3022 delta variant Delta variants effective electrostatic interaction elicited experiment Gamma H11-H4 health system IMPROVE increase Interaction investigated Lambda llama molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular mechanism molecular mechanisms nanobodies nanobody Neutralizing Neutralizing activity observation predict RBD recent Receptor binding domain reduce SARS-CoV-2 SARS-CoV-2 spike protein significantly Spike protein spread of COVID-19 the binding affinity the SARS-CoV-2 the spike protein Treatment Vaccine van der Waal variant variants of SARS-CoV-2 while [DOI] 10.1038/s41598-022-14263-1 PMC 바로가기 [Article Type] Article
Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants다양한 SARS-CoV-2 변이체의 검출을 위한 뉴클레오캡시드 특이적 진단Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] assays conserved COVID-19 pandemic CR3022 described detect detection diagnostics immune immunoassays immunofluorescence immunoplaque assay mutability Mutation N-terminal domain nanobody nucleocapsid nucleocapsid. Omicron variant Omicron variants Receptor binding S309 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Specific specific antibodies spike glycoprotein spike-specific antibodies Spike-specific antibody targets Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.926262 PMC 바로가기 [Article Type] Article
In silico study of substrate chemistry effect on the tethering of engineered antibodies for SARS-CoV-2 detection: Amorphous silica vs goldSARS-CoV-2 검출을 위한 조작된 항체의 테더링에 대한 기질 화학 효과의 실리코 연구: 비정질 실리카 대 금Article Published on 2022-05-012022-09-11 Journal: Colloids and surfaces. B, Biointerfaces [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] accelerated Affect Amorphous Amorphous silica antibodies antibody Antibody immobilization Arm correlation CR3022 cubic determined by Diagnosis Dynamics Effect electrostatic examined explain gold help IgG1 increase Interaction molecular molecular dynamics Orientation primary sequence Result S309 SARS-CoV-2 SARS-CoV-2 immunosensor. shape silica substrate tethering the antibodies the antibody tilt Two surface Two surfaces van der Waal [DOI] 10.1016/j.colsurfb.2022.112400 PMC 바로가기 [Article Type] Article
Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interactionSARS-CoV-2 스파이크 단백질의 수용체 결합 도메인에 있는 Y380Q 신규 돌연변이는 C379W와 함께 중화 항체 상호작용을 방해합니다Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] All participant All participants B.1.1.28 B.1.1.33 binding Brazil children circulating COVID-19 CR3022 cycle threshold domain enrolled EY6A High-throughput sequencing Interaction interfere Lineage Mutation Neutralizing antibodies neutralizing antibody novel Novel mutation Older pandemic participant performed Porto positive RBD Receptor-binding domain RT-PCR assay S gene SARS-CoV-2 SARS-CoV-2 spike protein Sequencing Signs and symptoms Spike protein submitted symptoms of COVID-19 tested the receptor-binding domain the SARS-CoV-2 the spike protein variants variants. Viral viral spike protein [DOI] 10.1016/j.diagmicrobio.2022.115636 PMC 바로가기 [Article Type] Article
Unravelling the molecular interactions between the SARS-CoV-2 RBD spike protein and various specific monoclonal antibodiesSARS-CoV-2 RBD 스파이크 단백질과 다양한 특정 단일클론항체 간의 분자 상호작용 규명Article Published on 2022-02-012022-09-12 Journal: Biochimie [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accelerated Accelerated molecular dynamics ACE2 ACE2 receptor approach cell receptor conformation Conformational study conformations COVID-19 disease CR3022 determine drugs epitope identify increase Interaction knowledge mAb mAbs molecular molecular interaction monoclonal antibody physiological conditions predominant protein-protein interaction RBD Result S protein S309 Salt Bridge SARS-CoV-2 SARS-CoV-2. spike glycoprotein Spike protein the RBD the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic option treat Vaccine virus [DOI] 10.1016/j.biochi.2021.10.013 PMC 바로가기 [Article Type] Article
In Planta Production of the Receptor-Binding Domain From SARS-CoV-2 With Human Blood Group A Glycan StructuresChemistry Published on 2022-02-012022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 receptor Affect Analysis antibody Antigen approach benthamiana binding Blood Group Blood group antigen carbohydrate cellular co-expressed complex contribute CR3022 domain ENhance Epitopes functional glycan glycoengineering glycosylated glycosylation group Human human sera IgG immune evasion immunogenic in vivo individual Interaction Modification N-glycan Nicotiana benthamiana non-infected performed plants posttranslational modification Production purified RBD recombinant SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sera serological assays shown Structure structures Subunit vaccine the RBD the SARS-CoV-2 variant Viral antigen viral envelope protein virus virus infection virus transmission [DOI] 10.3389/fchem.2021.816544 PMC 바로가기 [Article Type] Chemistry